RADIOIMMUNOASSAY OF MAMMALIAN TYPE C VIRAL PROTEINS
نویسندگان
چکیده
منابع مشابه
Radioimmunoassay of Mammalian Type C Viral Proteins
A radioimmunoassay specific for a murine leukemia virus structural protein, the gs antigen, detects an antigenic reactivity in normal murine cells in culture and natural tissues. The assay was shown to measure an antigen that is highly related to the virion protein as shown by absorption tests, immunoadsorbent chromatography, and by analysis of linearized dose-response curves. These findings co...
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Radioimmunological techniques were applied to the analysis of reverse transcriptase of mammalian type C RNA viruses. The polymerase of Rauscher mouse leukemia virus was purified by ion exchange and sequential affinity chromatography. Radioimmunoassays that utilized the viral enzyme as a probe detected as little as 1 ng of purified polymerase. No cross-reactivity could be demonstrated between th...
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Radioimmunological techniques were applied to the quantitation of the translational products of the gag, pol, and env genes of mammalian type C viruses. Analysis of the viral proteins associated with simian sarcoma-associated virus (SSA V) and SSA V-infected cells revealed in each that the level of reverse transcriptase was less than 1% of that of the major viral structural protein, p30. The ra...
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It is estimated that up to 20% of all types of human cancers worldwide are attributed to viruses. The genome of oncogenic viruses carries genes that have protein products that act as oncoproteins in cell proliferation and transformation. The modulation of cell cycle control mechanisms, cellular regulatory and signaling pathways by oncogenic viruses, plays an important role in viral carcinogenes...
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Anomalous boundaries resulting from the binding of a buffer constituent give the appearance of electrophoretic inhomogeneity to pure crystalline native monomeric cytochromes c from 10 species (man, horse, hog, guanaco, Pekin duck, pigeon, turkey, tuna, a moth (Samia cynfhia), and the screw worm fly). The electrophoretic patterns depend on the particular cytochrome c used and its concentration, ...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1973
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.137.3.622